Mammalian D-Cysteine controls insulin secretion in the pancreas

• Main Authors: Robin Roychaudhuri (Author), Timothy West (Author), Soumyaroop Bhattacharya (Author), Harry G. Saavedra (Author), Hangnoh Lee (Author), Lauren Albacarys (Author), Moataz M. Gadalla (Author), Mario Amzel (Author), Peixin Yang (Author), Solomon H. Snyder (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: D-amino acids are being recognized as important molecules in mammals with function. This is a first identification of endogenous D-cysteine in mammalian pancreas. Methods: Using a novel stereospecific bioluminescent assay, chiral chromatography, enzyme kinetics and a transgenic mouse mod...