DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD

• Main Authors: Jie Tan (Author), Jie Zhang (Author), Mengke Wang (Author), Yifen Wang (Author), Mengzhen Dong (Author), Xuefeng Ma (Author), Baokai Sun (Author), Shousheng Liu (Author), Zhenzhen Zhao (Author), Lizhen Chen (Author), Wenwen Jin (Author), Kai Liu (Author), Yongning Xin (Author), Likun Zhuang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA damage-regulated autophagy modulator 1 (DRAM1) could play important roles in inflammation and hepatic apoptosis, while its roles in alcohol-related liver disease (ALD), which is characterized by hepatic inflammation and apoptosis, are still unclear. In this study, we explored the expression, rol...