Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

Abstract Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates....

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Main Authors: Fauzia Nasim (Author), Diethart Schmid (Author), Gergely Szakács (Author), Azmat Sohail (Author), Harald H. Sitte (Author), Peter Chiba (Author), Thomas Stockner (Author)
Format: Book
Published: Wiley, 2020-04-01T00:00:00Z.
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