Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

• Главные авторы: Fauzia Nasim (Автор), Diethart Schmid (Автор), Gergely Szakács (Автор), Azmat Sohail (Автор), Harald H. Sitte (Автор), Peter Chiba (Автор), Thomas Stockner (Автор)
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• Опубликовано: Wiley, 2020-04-01T00:00:00Z.
• Предметы: article
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Abstract Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates....