Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

• Main Authors: Tony Taldone (Author), Victoria Gillan (Author), Weilin Sun (Author), Anna Rodina (Author), Pallav Patel (Author), Kirsty Maitland (Author), Kerry O'Neill (Author), Gabriela Chiosis (Author), Eileen Devaney (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adu...