Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospacer adjacent motif (PAM) at the target locus and is limited to a window within the CRISPR-Cas R-loop...

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Main Authors: Lukas Villiger (Author), Lukas Schmidheini (Author), Nicolas Mathis (Author), Tanja Rothgangl (Author), Kim Marquart (Author), Gerald Schwank (Author)
Format: Book
Published: Elsevier, 2021-12-01T00:00:00Z.
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3rd Floor Main Library

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