Cover Image

Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of Acetaminophen

Interindividual variability in polymorphic uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) ascribed to genetic diversity is associated with relative glucuronidation level among individuals. The present research was aimed to study the effect of 2 important single nucleotide polymorphisms (SN...

Full description

Saved in:

Bibliographic Details
Main Authors:	Huma Mehboob (Author), Imtiaz Mahmood Tahir (Author), Tahira Iqbal (Author), Sadaf Saleem (Author), Sofia Perveen (Author), Aboubakker Farooqi (Author)
Format:	Book
Published:	SAGE Publishing, 2017-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis
by: Wanying Zeng, et al.
Published: (2022)

Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite
by: Shuaibing Liu, et al.
Published: (2021)

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)
by: Xu-Xin Zhang, et al.
Published: (2017)

Age-dependent Hepatic UDP-glucuronosyltransferase Gene Expression and Activity in Children
by: Elizabeth Neumann, et al.
Published: (2016)

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro
by: Xia-Wen Liu, et al.
Published: (2018)

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
by: Lucas Zhou, et al.
Published: (2023)

Structure and protein-protein interactions of human UDP-glucuronosyltransferases
by: Ryoichi Fujiwara, et al.
Published: (2016)

Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis.
by: Alexander F Flynn, et al.
Published: (2019)

Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells
by: Monivan Chhour, et al.
Published: (2021)

Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7
by: Jia Xue, et al.
Published: (2022)

Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
by: Yun Sheng, et al.
Published: (2021)

UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European data
by: Apolonia Novillo, et al.
Published: (2018)

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1
by: Xuewei Cheng, et al.
Published: (2017)

Effects of variation status and enzyme activity for UDP-glucuronosyltransferase 1A1 gene on neonatal hyperbilirubinemia
by: May-Jen Huang, et al.
Published: (2020)

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
by: Riya Shrestha, et al.
Published: (2018)

Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes
by: Deok-Kyu Hwang, et al.
Published: (2019)

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function?
by: Yuejian Liu, et al.
Published: (2017)

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α
by: Sung-joon Cho, et al.
Published: (2016)

Pharmacokinetic drug-drug interactions of JBPOS0101 mediated by cytochrome P450 3A4 and UDP‐glucuronosyltransferases
by: Sejung Hwang, et al.
Published: (2024)

Molecular biology of glucose-6-phosphate dehydrogenase and UDP-glucuronosyltransferase 1A1 in the development of neonatal unconjugated hyperbilirubinemia
by: Yi-Li Hung, et al.
Published: (2024)

Prevalence of UDP-glucuronosyltransferase polymorphisms (UGT1A6∗2, 1A7∗12, 1A8∗3, 1A9∗3, 2B7∗2, and 2B15∗2) in a
by: Khalid M. Alkharfy, et al.
Published: (2017)

The pharmaceutical excipient PEG400 affect the absorption of baicalein in Caco‐2 monolayer model by interacting with UDP‐glucuronosyltransferases and efflux transport proteins
by: Siyuan Cao, et al.
Published: (2022)

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases
by: Jiří Vrba, et al.
Published: (2021)

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1
by: Hui-Lin Pang, et al.
Published: (2022)

Frequency of dihydropyrimidine dehydrogenase and UDP-glucuronosyltransferase 1A1 variants in cancer patients requiring chemotherapy: A single-center study in southern India
by: Kevin Nischay Gangavarapu, et al.
Published: (2023)

INTRODUCTION OF AN N-GLYCOSYLATION SITE INTO UDP-GLUCURONOSYLTRANSFERASE 2B3 ALTERS ITS SENSITIVITY TO CYTOCHROME P450 3A1-DEPENDENT MODULATION
by: Tatsuro Nakamura, et al.
Published: (2016)

Tetrahydrofurofuranoid Lignans, Eudesmin, Fargesin, Epimagnolin A, Magnolin, and Yangambin Inhibit UDP-Glucuronosyltransferase 1A1 and 1A3 Activities in Human Liver Microsomes
by: Ria Park, et al.
Published: (2021)

Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions
by: Zifei Qin, et al.
Published: (2020)

Association Between rs12037447, rs146732504, rs151078858, rs55723436, and rs6094136 Polymorphisms and Kawasaki Disease in the Population of Polish Children
by: Piotr Buda, et al.
Published: (2021)

Gene Polymorphisms in FAS (Rs3740286 and Rs4064) Are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815)
by: Cristina Wide Pissetti, et al.
Published: (2018)

The Use of Estrone-3-Glucuronide and Pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity
by: Leonard F. Blackwell, et al.
Published: (2018)

Comments on: Gene Polymorphisms in FAS (Rs3740286 and Rs4064) are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815)
by: Fabio Barra, et al.
Published: (2018)

IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis
by: Xiaoli Liu, et al.
Published: (2024)

UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease
by: He-Ping Lei, et al.
Published: (2021)

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors
by: Zifei Qin, et al.
Published: (2019)

The three CYBA variants (rs4673, rs1049254 and rs1049255) are benign: new evidence from a patient with CGD
by: Jinqiao Sun, et al.
Published: (2017)

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major.
by: Sebastian Damerow, et al.
Published: (2015)

Association of polymorphisms rs2303729, rs10880, and rs1131620 of LTBP4 with sarcopenia in elderly patients with type 2 diabetes mellitus
by: Ingrid Yali Ibarra-Tapia, et al.
Published: (2022)

Correction: Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major.
by: Sebastian Damerow, et al.
Published: (2016)

Assessment of post-menopausal osteoporosis development risk: role of polymorphisms RS1800012, RS1107946 of a gene of COL1A1 and RS731236 and RS11568820 of a gene of VDR
by: D. S. Zyablicev, et al.
Published: (2015)