mTOR Inhibition Impairs the Activation and Function of Belatacept-Resistant CD4⁺CD57⁺ T Cells In Vivo and In Vitro

• Main Authors: Florence Herr (Author), Manon Dekeyser (Author), Jerome Le Pavec (Author), Christophe Desterke (Author), Andrada-Silvana Chiron (Author), Karen Bargiel (Author), Olaf Mercier (Author), Amelia Vernochet (Author), Elie Fadel (Author), Antoine Durrbach (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcineurin inhibitors have improved graft survival in solid-organ transplantation but their use is limited by toxicity, requiring a switch to another immunosuppressor in some cases. Belatacept is one option that has been shown to improve graft and patient survival despite being associated with a hi...