mTORC1 is required for epigenetic silencing during β-cell functional maturation

• Main Authors: Qicheng Ni (Author), Jiajun Sun (Author), Yichen Wang (Author), Yanqiu Wang (Author), Jingwen Liu (Author), Guang Ning (Author), Weiqing Wang (Author), Qidi Wang (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is a key molecule that links nutrients, hormones, and growth factors to cell growth/function. Our previous studies have shown that mTORC1 is required for β-cell functional maturation and identity maintenance; however, the underlying m...