Calcium-Dependent Src Phosphorylation and Reactive Oxygen Species Generation Are Implicated in the Activation of Human Platelet Induced by Thromboxane A2 Analogs

• Main Authors: Pietro Minuz (Author), Alessandra Meneguzzi (Author), Laura Fumagalli (Author), Maurizio Degan (Author), Stefano Calabria (Author), Roberta Ferraro (Author), Marco Ricci (Author), Dino Veneri (Author), Giorgio Berton (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The thromboxane (TX) A2 elicits TP-dependent different platelet responses. Low amounts activate Src kinases and the Rho-Rho kinase pathway independently of integrin αIIbβ3 and ADP secretion and synergize with epinephrine to induce aggregation. Aim of the present study was to investigate the role Src...