Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities

• Main Authors: Samia G. Abdel Moty (Author), Mostafa A. Hussein (Author), Salah A. Abdel Aziz (Author), Mahrous A. Abou-Salim (Author)
• Formato: Libro
• Publicado: Elsevier, 2016-03-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

In continuation to our previous work, thiazolopyrimidines 2a-x were synthesized through intramolecular cyclization of 2-phenacylthio-dihydropyrimidine hydrobromides 1a-x using polyphosphoric acid. On the other hand, thiazolo[3,2-a]pyrimidine-3-one 3 was coupled with aryldiazonium salts or condensed...