Effect of CYP3A4 Inhibitors and Inducers on Pharmacokinetics and Pharmacodynamics of Saxagliptin and Active Metabolite M2 in Humans Using Physiological-Based Pharmacokinetic Combined DPP-4 Occupancy

• Main Authors: Gang Li (Author), Bowen Yi (Author), Jingtong Liu (Author), Xiaoquan Jiang (Author), Fulu Pan (Author), Wenning Yang (Author), Haibo Liu (Author), Yang Liu (Author), Guopeng Wang (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We aimed to develop a physiological-based pharmacokinetic and dipepidyl peptidase 4 (DPP-4) occupancy model (PBPK-DO) characterized by two simultaneous simulations to predict pharmacokinetic (PK) and pharmacodynamic changes of saxagliptin and metabolite M2 in humans when coadministered with CYP3A4 i...