Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

• Main Authors: Andrea Medeiros (Author), Diego Benítez (Author), Ricarda S. Korn (Author), Vinicius C. Ferreira (Author), Exequiel Barrera (Author), Federico Carrión (Author), Otto Pritsch (Author), Sergio Pantano (Author), Conrad Kunick (Author), Camila I. de Oliveira (Author), Oliver C. F. Orban (Author), Marcelo A. Comini (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report the mechanistic and biological characterisati...