Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania
Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report the mechanistic and biological characterisati...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Taylor & Francis Group,
2020-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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