BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters

• Main Authors: Diana H. Chin (Author), Issra Osman (Author), Jadon Porch (Author), Hyunmin Kim (Author), Kristen K. Buck (Author), Javier Rodriguez (Author), Bianca Carapia (Author), Deborah Yan (Author), Stela B. Moura (Author), Jantzen Sperry (Author), Jonathan Nakashima (Author), Kasey Altman (Author), Delsee Altman (Author), Berkley E. Gryder (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs). P3F recruits co-regulatory fac...