Remyelination-Promoting DNA Aptamer Conjugate Myaptavin-3064 Binds to Adult Oligodendrocytes In Vitro

• Main Authors: Mahboubeh Fereidan-Esfahani (Author), Wei Ying Yue (Author), Brandon Wilbanks (Author), Aaron J. Johnson (Author), Arthur E. Warrington (Author), Charles L. Howe (Author), Moses Rodriguez (Author), Louis J. Maher (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously applied Systematic Evolution of Ligands by EXponential enrichment (SELEX) technology to identify myelin-specific DNA aptamers, using crude mouse central nervous system myelin as bait. This selection identified a 40-nucleotide aptamer (LJM-3064). Multiple biotinylated LJM-3064 molecules...