Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury

• Main Authors: Limei Wan (Author), Weibin Wu (Author), Shunjun Jiang (Author), Shanhe Wan (Author), Dongmei Meng (Author), Zhipeng Wang (Author), Jiajie Zhang (Author), Li Wei (Author), Pengjiu Yu (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have illuminated that blocking Ca2+ influx into effector cells is an attractive therapeutic strategy for lung injury. We hypothesize that T-type calcium channel may be a potential therapeutic target for acute lung injury (ALI). In this study, the pharmacological activity of mibefradil...