In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan

• Main Authors: Hiroyuki Fujiki (Author), Masayuki Matsunaga (Author), Masayuki Furukawa (Author), Tatsuya Yamashita (Author), Shigeki Nakamura (Author), Toshiki Miyazaki (Author), Hiroshi Mizuguchi (Author), Yasuhiro Menjo (Author), Takakuni Matsuda (Author), Yoshihisa Yamada (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tolvaptan is an orally active vasopressin V2 receptor antagonist and used for the treatment of volume overload in some disease as an aquaretic. Tolvaptan sodium phosphate (OPC-61815) is a pro-drug of tolvaptan that was designed to improve water solubility and enable intravenous use. The conversion o...