Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models

• Main Authors: Alia M. Obeidat (Author), Shingo Ishihara (Author), Jun Li (Author), Natalie S. Adamczyk (Author), Lindsey Lammlin (Author), Lucas Junginger (Author), Tristan Maerz (Author), Richard J. Miller (Author), Rachel E. Miller (Author), Anne-Marie Malfait (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectiveKnee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and late-stage OA, using four distinct experimental mouse...