Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening

• Main Authors: Barbara Garofalo (Author), Federica Prati (Author), Rosa Buonfiglio (Author), Isabella Coletta (Author), Noemi D'Atanasio (Author), Angela Molteni (Author), Daniele Carettoni (Author), Valeria Wanke (Author), Giorgio Pochetti (Author), Roberta Montanari (Author), Davide Capelli (Author), Claudio Milanese (Author), Francesco Paolo Di Giorgio (Author), Rosella Ombrato (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The major cause of bacterial resistance to β-lactams is the production of hydrolytic β-lactamase enzymes. Nowadays, the combination of β-lactam antibiotics with β-lactamase inhibitors (BLIs) is the main strategy for overcoming such issues. Nevertheless, particularly challenging β-lactamases, such as...