Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma

• Main Authors: Renren Bai (Author), Junlong Zhu (Author), Ziqiang Bai (Author), Qing Mao (Author), Yingqian Zhang (Author), Zi Hui (Author), Xinyu Luo (Author), Xiang-Yang Ye (Author), Tian Xie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elemene is a second-line broad-spectrum anti-tumour drug that has been used in China for more than two decades. However, its main anti-tumour ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumour efficacy. To improve the anti-tumour activity of β...