Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells

• Main Authors: Maxim S. Kupryushkin (Author), Anton V. Filatov (Author), Nadezhda L. Mironova (Author), Olga A. Patutina (Author), Ivan V. Chernikov (Author), Elena L. Chernolovskaya (Author), Marina A. Zenkova (Author), Dmitrii V. Pyshnyi (Author), Dmitry A. Stetsenko (Author), Sidney Altman (Author), Valentin V. Vlassov (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3' and 5' ends were prepared via the Staudinger chemistry, which is compatible with conditions of standard auto...