In Vitro Metabolism Study of Seongsanamide A in Human Liver Microsomes Using Non-Targeted Metabolomics and Feature-Based Molecular Networking

• Main Authors: Zhexue Wu (Author), Geum Jin Kim (Author), So-Young Park (Author), Jong Cheol Shon (Author), Kwang-Hyeon Liu (Author), Hyukjae Choi (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Seongsanamide A is a bicyclic peptide with an isodityrosine residue discovered in <i>Bacillus safensis</i> KCTC 12796BP which exhibits anti-allergic activity in vitro and in vivo without significant cytotoxicity. The purpose of this study was to elucidate the in vitro metabolic pathway a...