Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

• Main Authors: Andrea Bistrović (Author), Petra Grbčić (Author), Anja Harej (Author), Mirela Sedić (Author), Sandra Kraljević-Pavelić (Author), Sanja Koštrun (Author), Janez Plavec (Author), Damjan Makuc (Author), Silvana Raić-Malić (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on pancreatic adenocarcinoma cells CFPAC-1,1-(p-...