Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

• Autores principales: Andrea Bistrović (Autor), Petra Grbčić (Autor), Anja Harej (Autor), Mirela Sedić (Autor), Sandra Kraljević-Pavelić (Autor), Sanja Koštrun (Autor), Janez Plavec (Autor), Damjan Makuc (Autor), Silvana Raić-Malić (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on pancreatic adenocarcinoma cells CFPAC-1,1-(p-...