Effects of hypnotic bromovalerylurea on microglial BV2 cells

• Main Authors: Shun Kawasaki (Author), Naoki Abe (Author), Fumito Ohtake (Author), Afsana Islam (Author), Mohammed Emamussalehin Choudhury (Author), Ryo Utsunomiya (Author), Satoshi Kikuchi (Author), Tasuku Nishihara (Author), Jun Kuwabara (Author), Hajime Yano (Author), Yuji Watanabe (Author), Mayuki Aibiki (Author), Toshihiro Yorozuya (Author), Junya Tanaka (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An old sedative and hypnotic bromovalerylurea (BU) has anti-inflammatory effects. BU suppressed nitric oxide (NO) release and proinflammatory cytokine expression by lipopolysaccharide (LPS)-treated BV2 cells, a murine microglial cell line. However, BU did not inhibit LPS-induced nuclear translocatio...