Linoleate-pazopanib conjugation as active pharmacological ingredient to abolish hepatocellular carcinoma growth

• Main Authors: Ke Wang (Author), Pei-Yin Liao (Author), Wei-Chun Chang (Author), Cian-Ru Yang (Author), Yu-Ting Su (Author), Ping-Ching Wu (Author), Yang-Chang Wu (Author), Yao-Ching Hung (Author), Najim Akhtar (Author), Hsueh-Chou Lai (Author), Wen-Lung Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small molecule compounds targeting multiple kinases involved in neoangiogenesis have shown survival benefits in patients with unresectable hepatocellular carcinoma (HCC). Nonetheless, despite the beneficial effects of multikinase inhibitors (MKIs), a lack of boosting adjuvant limits their objective...