Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

• Main Authors: Lijun Cheng (Author), Pankita H. Pandya (Author), Enze Liu (Author), Pooja Chandra (Author), Limei Wang (Author), Mary E. Murray (Author), Jacquelyn Carter (Author), Michael Ferguson (Author), Mohammad Reza Saadatzadeh (Author), Khadijeh Bijangi-Visheshsaraei (Author), Mark Marshall (Author), Lang Li (Author), Karen E. Pollok (Author), Jamie L. Renbarger (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background While most pediatric sarcomas respond to front-line therapy, some bone sarcomas do not show radiographic response like soft-tissue sarcomas (rhabdomyosarccomas) but do show 90% necrosis. Though, new therapies are urgently needed to improve survival and quality of life in pediatri...