Tetrandrine inhibits aldosterone synthesis by covalently targeting CYP11A1 to attenuate hypertension

• Main Authors: Simeng Chu (Author), Wei Yang (Author), Yujie Lu (Author), Junjie Li (Author), Jiamin Peng (Author), Wenjuan Liu (Author), Min Jiang (Author), Gang Bai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionTetrandrine (Tet) is the main pharmacological component of Stephania tetrandra S. Moore, which is a well-documented traditional Chinese medicine known for its diuretic and antihypertensive properties. Unraveling the specific targets and mechanisms of Tet involved in inducing diuresis and...