Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping

Polysorbates are an important class of nonionic surfactants that are widely used to stabilize biopharmaceuticals. The degradation of polysorbate 20 and 80 and the related particle formation in biologics are heavily discussed in the pharmaceutical community. Although a lot of experimental effort was...

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Main Authors: Judith J. Mittag (Author), Marie-Luise Trutschel (Author), Helen Kruschwitz (Author), Karsten Mäder (Author), Julia Buske (Author), Patrick Garidel (Author)
Format: Book
Published: Elsevier, 2022-12-01T00:00:00Z.
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