Development of Level A In Vitro-Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

• Hauptverfasser: Dong-Seok Lee (Verfasst von), Dong Wook Kang (Verfasst von), Go-Wun Choi (Verfasst von), Han-Gon Choi (Verfasst von), Hea-Young Cho (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2020-01-01T00:00:00Z.
• Schlagworte: article
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This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution. The pharmacokinetic (PK) and pharmacodynamic (PD) study of leuproli...