Development of Level A In Vitro-Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

• Egile Nagusiak: Dong-Seok Lee (Egilea), Dong Wook Kang (Egilea), Go-Wun Choi (Egilea), Han-Gon Choi (Egilea), Hea-Young Cho (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution. The pharmacokinetic (PK) and pharmacodynamic (PD) study of leuproli...