The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand

• Main Authors: Hyunbae Kim (Author), Zhiyao Fu (Author), Zhao Yang (Author), Zhenfeng Song (Author), El Hussain Shamsa (Author), Thangal Yumnamcha (Author), Shengyi Sun (Author), Wanqing Liu (Author), Ahmed S. Ibrahim (Author), Nathan R. Qi (Author), Ren Zhang (Author), Kezhong Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (MNADK) mediates de novo mitochondrial NADP biosynthesis by catalyzing the phosphorylation of NAD to yield NADP. In this study, we investigated the function and mechanistic basis by which MNADK regulates metabolic homeostasi...