Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway

• Main Authors: Yijing Zhao (Author), Lei Zhou (Author), Hui Li (Author), Tingge Sun (Author), Xue Wen (Author), Xueli Li (Author), Ying Meng (Author), Yan Li (Author), Mengmeng Liu (Author), Shanshan Liu (Author), Su-Jeong Kim (Author), Jialin Xiao (Author), Lingyu Li (Author), Songling Zhang (Author), Wei Li (Author), Pinchas Cohen (Author), Andrew R. Hoffman (Author), Ji-Fan Hu (Author), Jiuwei Cui (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial dysfunction is a metabolic hallmark of cancer cells. In search of molecular factors involved in this dysregulation in hepatocellular carcinoma (HCC), we found that the nuclear-encoded long noncoding RNA (lncRNA) MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was aberra...