Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis

• Main Authors: Shilong Zhang (Author), Zanjie Feng (Author), Weidong Gao (Author), Yuling Duan (Author), Guoxin Fan (Author), Xin Geng (Author), Bo Wu (Author), Kai Li (Author), Kangwei Liu (Author), Cijun Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver ischemia-reperfusion injury (IRI) is a common clinical event with high morbidity in patients undergoing complex liver surgery or having abdominal trauma. Inflammatory and oxidative stress responses are the main contributing factors in liver IRI. The iridoid glucoside aucubin (AU) has good anti...