HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

• Principais autores: Angela S. Brijmohan (Autor), Sri N. Batchu (Autor), Syamantak Majumder (Autor), Tamadher A. Alghamdi (Autor), Karina Thieme (Autor), Sarah McGaugh (Autor), Youan Liu (Autor), Suzanne L. Advani (Autor), Bridgit B. Bowskill (Autor), M. Golam Kabir (Autor), Laurette Geldenhuys (Autor), Ferhan S. Siddiqi (Autor), Andrew Advani (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

To contend with the deleterious effects of accumulating misfolded protein aggregates or damaged organelles cells rely on a system of quality control processes, among them the autophagy-lysosome pathway. This pathway is itself controlled by a master regulator transcription factor termed transcription...