Untargeted metabolomics reveals dose-response characteristics for effect of rhubarb in a rat model of cholestasis

• Main Authors: Cong-En eZhang (Author), Ming eNiu (Author), Rui-yu eLi (Author), Wu-Wen eFeng (Author), Xiao eMa (Author), Qin eDong (Author), Zhi-jie eMa (Author), Guang-Quan eLi (Author), Ya-Kun eMeng (Author), Ya eWang (Author), Ping eYin (Author), Lan-Zhi eHe (Author), Yu-Meng eLi (Author), Peng eTan (Author), Yan-ling eZhao (Author), Jia-Bo eWang (Author), Xiao-ping eDong (Author), Xiao-he eXiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholestasis is a serious manifestation of liver diseases with limited therapies. Rhubarb, a widely used herbal medicine, has been frequently used at a relatively large dose for treating cholestasis. However, whether large doses are optimal and the therapeutic mechanism remain unclear. To explore the...