Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention

• Egile Nagusiak: Debarshi Mustafi (Egilea), Amirmohsen Arbabi (Egilea), Hossein Ameri (Egilea), Krzysztof Palczewski (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2019-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The advent of genetic therapies for inherited retinal diseases (IRDs) has spurred the need for precise diagnosis and understanding of pathways for therapeutic targeting. The majority of IRDs that are clinically diagnosed, however, lack an identifiable mutation in established disease-causing loci and...