PP2A regulates metastasis and vasculogenic mimicry formation via PI3K/AKT/ZEB1 axis in non-small cell lung cancers

• Autors principals: Yu Zhang (Autor), Xingchen Wang (Autor), Anqi Li (Autor), Yanhui Guan (Autor), Peibo Shen (Autor), Yingqian Ni (Autor), Xiuzhen Han (Autor)
• Format: Llibre
• Publicat: Elsevier, 2022-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Studies have shown that inhibition of PI3K/AKT signaling is a key strategy for the treatment of tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Vasculogenic mimicry (VM) not only accelerates tumor progression but also increases drug-induced resistance. As a tumor suppress...