Cannabidiol-Loaded Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Paclitaxel-Induced Peripheral Neuropathy

• Main Authors: Anil Kumar Kalvala (Author), Arvind Bagde (Author), Peggy Arthur (Author), Tanmay Kulkarni (Author), Santanu Bhattacharya (Author), Sunil Surapaneni (Author), Nil Kumar Patel (Author), Ramesh Nimma (Author), Aragaw Gebeyehu (Author), Nagavendra Kommineni (Author), Yan Li (Author), David G. Meckes (Author), Li Sun (Author), Bipika Banjara (Author), Keb Mosley-Kellum (Author), Thanh Cong Dinh (Author), Mandip Singh (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In cancer patients, chronic paclitaxel (PTX) treatment causes excruciating pain, limiting its use in cancer chemotherapy. The neuroprotective potential of synthetic cannabidiol (CBD) and CBD formulated in extracellular vesicles (CBD-EVs) isolated from human umbilical cord derived mesenchymal stem ce...