Comparison of P‐glycoprotein function in peripheral blood mononuclear cells ex vivo in stable Black and White male and female kidney transplant recipients

• Main Authors: Kathleen M. Tornatore (Author), Kris Attwood (Author), Daniel Brazeau (Author), Jason Sprowl (Author), Shirley Chang (Author), Aijaz Gundroo (Author), Hans Minderman (Author), Rocco C. Venuto (Author)
• Format: Book
• Published: Wiley, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Kidney allograft survival remains poorer in Black compared to White recipients due to racial differences in calcineurin inhibitor (CNI) pharmacology. P‐glycoprotein (P‐gp), an ABC efflux transporter expressed in peripheral blood mononuclear cells (PBMCs), modulates CNI pharmacokinetics and...