Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma

• Main Authors: Lucia Cottone (Author), Nadia Eden (Author), Inga Usher (Author), Patrick Lombard (Author), Hongtao Ye (Author), Lorena Ligammari (Author), Daniel Lindsay (Author), Sebastian Brandner (Author), Jože Pižem (Author), Nischalan Pillay (Author), Roberto Tirabosco (Author), Fernanda Amary (Author), Adrienne M Flanagan (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The expression of p16/CDKN2A, the second most commonly inactivated tumour suppressor gene in cancer, is lost in the majority of chordomas. However, the mechanism(s) leading to its inactivation and contribution to disease progression have only been partially addressed using small patient coh...