Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA

• Main Authors: Junpei Yamaguchi (Author), Teruhisa Manome (Author), Yasumasa Hara (Author), Yuriko Yamazaki (Author), Yuumi Nakamura (Author), Masami Ishibashi (Author), Akiko Takaya (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The virulence of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), depends on the expression of toxins and virulence factors controlled by the quorum-sensing (QS) system, encoded on the virulence accessory gene regulator (agr) locus. The aim of this study was to identify a phy...