Blends of hydrophobic and swelling agents in the swelling layer in the preparation of delayed-release pellets of a hydrophilic drug with low MW: Physicochemical characterizations and in-vivo evaluations

• Główni autorzy: Chang You (Autor), Xuedan Liang (Autor), Jiabei Sun (Autor), Lin Sun (Autor), Yitao Wang (Autor), Tianyuan Fan (Autor), Ying Zheng (Autor)
• Format: Książka
• Wydane: Elsevier, 2014-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

In this study, a hydrophobic material, ethylcellulose, which was used as its aqueous suspension Surelease®, was combined with a swelling agent as the swelling layer to prepare delayed-release pellets for Danshensu, which is a hydrophilic drug with low MW. A rupturable, delayed-release pellet consist...