Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts

• Main Authors: Jennifer L. Philip (Author), Md. Abdur Razzaque (Author), Mei Han (Author), Jinju Li (Author), Tiju Theccanat (Author), Xianyao Xu (Author), Shahab A. Akhter (Author)
• Format: Book
• Published: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH oxidase 4 (Nox4) is a major source of cardiac reactive oxygen species (ROS); however, mechanisms of Nox4 regulation...