Optimized 5-Fluorouridine Prodrug for Co-Loading with Doxorubicin in Clinically Relevant Liposomes

• Main Authors: Debra Wu (Author), Douglas Vogus (Author), Vinu Krishnan (Author), Marta Broto (Author), Anusha Pusuluri (Author), Zongmin Zhao (Author), Neha Kapate (Author), Samir Mitragotri (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liposome-based drug delivery systems have allowed for better drug tolerability and longer circulation times but are often optimized for a single agent due to the inherent difficulty of co-encapsulating two drugs with differing chemical profiles. Here, we design and test a prodrug based on a ribosyla...