An Enhanced Dissolving Cyclosporin-A Inhalable Powder Efficiently Reduces SARS-CoV-2 Infection In Vitro

• Main Authors: Davide D'Angelo (Author), Eride Quarta (Author), Stefania Glieca (Author), Giada Varacca (Author), Lisa Flammini (Author), Simona Bertoni (Author), Martina Brandolini (Author), Vittorio Sambri (Author), Laura Grumiro (Author), Giulia Gatti (Author), Giorgio Dirani (Author), Francesca Taddei (Author), Annalisa Bianchera (Author), Fabio Sonvico (Author), Ruggero Bettini (Author), Francesca Buttini (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work illustrates the development of a dry inhalation powder of cyclosporine-A for the prevention of rejection after lung transplantation and for the treatment of COVID-19. The influence of excipients on the spray-dried powder's critical quality attributes was explored. The best-performing...