Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice

• Main Authors: Astrid M. Schoppa (Author), Xiangxu Chen (Author), Jan-Moritz Ramge (Author), Anna Vikman (Author), Verena Fischer (Author), Melanie Haffner-Luntzer (Author), Jana Riegger (Author), Jan Tuckermann (Author), Karin Scharffetter-Kochanek (Author), Anita Ignatius (Author)
• Format: Book
• Published: The Company of Biologists, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) and arises in the aging organism, is considered one of the critical factors...