REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

REL-1017 (esmethadone; dextromethadone; (S)-methadone) is the opioid-inactive dextro-isomer of the racemic mixture, (R, S)-methadone. REL-1017 acts as a low affinity, low potency N-methyl-D-aspartate receptor (NMDAR) channel blocker with rapid, robust, and sustained therapeutic effects in patients w...

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Bibliographic Details
Main Authors: Francesco Bifari (Author), Marco Pappagallo (Author), Michael Bleavins (Author), Sergio Traversa (Author), Franco Folli (Author), Paolo L. Manfredi (Author)
Format: Book
Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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3rd Floor Main Library

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