Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques.

• Main Authors: Travis K Warren (Author), Chris A Whitehouse (Author), Jay Wells (Author), Lisa Welch (Author), Jay S Charleston (Author), Alison Heald (Author), Donald K Nichols (Author), Marc E Mattix (Author), Gustavo Palacios (Author), Jeffrey R Kugleman (Author), Patrick L Iversen (Author), Sina Bavari (Author)
• 格式: 图书
• 出版: Public Library of Science (PLoS), 2016-02-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene,...