Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration

• Main Authors: Anthony Altieri (Author), Hadeesha Piyadasa (Author), Mahadevappa Hemshekhar (Author), Natasha Osawa (Author), Breann Recksiedler (Author), Victor Spicer (Author), Pieter S Hiemstra (Author), Andrew J Halayko (Author), Neeloffer Mookherjee (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, along with the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Although IL-17A/F and TNF-α are known to functionally cooperate to exacerbate airway inf...