Purification Process of a Recombinant Human Follicle Stimulating Hormone Biosimilar (Primapur^®) to Yield a Pharmaceutical Product with High Batch-to-Batch Consistency

• Main Authors: Maria Sinegubova (Author), Ivan Vorobiev (Author), Anatoly Klishin (Author), Dmitry Eremin (Author), Nadezhda Orlova (Author), Natalya Orlova (Author), Mikhail Polzikov (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recombinant human follicle stimulating hormone (r-hFSH) is widely used for infertility treatment and is subject to the development of biosimilars. There are different purification strategies that can yield r-hFSH of pharmaceutical quality from Chinese hamster ovary cell culture broth. We developed a...